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KMID : 0985420210430030138
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Laboratory Medicine and Quality Assurance
2021 Volume.43 No. 3 p.138 ~ p.142
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Clinical Utility of Reticulocyte Hemoglobin Equivalent in Diagnosing Iron Deficiency Anemia
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Park Kyoung-Jin
Kim Moon-Jung
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Abstract
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Background: Iron deficiency anemia (IDA) is one of the major global public health problems. Reticulocyte hemoglobin (Hb) equivalent (Ret-He) has been proposed as an early index for IDA. However, little information is available regarding the Ret-He in Korean patients with IDA. We aimed to investigate the clinical utility of Ret-He as a diagnostic index in Korean patients with IDA.
Methods: Laboratory data, including complete blood count and iron metabolism markers, were retrospectively reviewed. In total, 507 individuals were categorized into four groups based on Hb and iron index: iron deficiency (ID, n=21), IDA (n=254), non-IDA (n=150), and healthy control (HC, n=82). Receiver operating characteristic analysis was performed to evaluate the diagnostic power of Ret-He.
Results: The Ret-He levels from the ID and IDA groups were significantly lower than those from the non-IDA and HC groups (P-value <0.0001; median Ret-He: 32.2 pg for ID; 29.7 pg for IDA; 33.9 pg for non-IDA; and 34.5 pg for HC). The area under the curve of Ret-He was 0.851 at a cutoff of 32.3 pg, by which IDA was discriminated from HC (sensitivity of 72% and specificity of 90%).
Conclusions: This study suggests that Ret-He could be an alternative hematologic index for the diagnosis of IDA. Further prospective clinical studies are warranted to validate the clinical utility of Ret-He and to integrate it into the diagnostic algorithm for IDA.
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KEYWORD
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Reticulocyte hemoglobin equivalent, Ferritina, Iron-deficiency anemia, Anemia, Korean
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